Wissenschaftliche Medizin > Diagnostika, neue Verfahren

Alzheimer: Früherkennung mit Infrarot


Sun Mar 16 19:42:07 2008 (Optical Society of America)

Light Waves Can Detect Alzheimer's Disease Early On, Study Suggests

A team of researchers in Bedford, Mass. has developed a way of examining
brain tissue with near-infrared light to detect signs of Alzheimer's
In the journal Optics Letters, the team describes how they used optical
technology to examine tissue samples taken from different autopsies and
correctly identified which samples came from people who had Alzheimer's
disease. Alzheimer's currently afflicts some 4.5 million Americans and is
the most common cause of dementia among older people in the United States.

Journal reference:
"Scattering Differentiates Alzheimer Disease In Vitro,"
by Eugene B. Hanlon et al., Optics Letters, Vol. 33, No. 6, March 15,
pp. 624-26, abstract at


The abstract:


Optics InfoBase
Published by The Optical Society of America
Scattering differentiates Alzheimer disease in vitro

Eugene B. Hanlon, Lev T. Perelman, Eduard I. Vitkin, Frank A. Greco,
Ann C. McKee, and Neil W. Kowall
Optics Letters, Vol. 33, Issue 6, pp. 624-626
Keywords (OCIS):
(170.0170) Medical optics and biotechnology : Medical optics and
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue
(290.5825) Scattering : Scattering theory


The molecular bases of Alzheimer disease and related neurodegenerative
disorders are becoming better understood, but the means for definitive
diagnosis and monitoring in vivo remain lacking. Near-infrared optical
spectroscopy offers a potential solution. We acquired transmission and
reflectance spectra of thin brain tissue slabs, from which we calculated
wavelength-dependent absorption and reduced scattering coefficients from
470-1000 nm. The reduced scattering coefficients in the near infrared
clearly differentiated Alzheimer from control specimens. Diffuse
reflectance spectra of gross brain tissue in vitro confirmed this
observation. These results suggest a means for diagnosing and monitoring
Alzheimer disease in vivo, using near-infrared optical spectroscopy.

© 2008 Optical Society of America

View Full Text: PDF (271 KB)

Original Manuscript: November 20, 2007
Manuscript Accepted: February 8, 2008
Revised Manuscript: February 6, 2008
Published: March 14, 2008
E. B. Hanlon, L. T. Perelman, E. I. Vitkin, F. A. Greco, A. C. McKee, and N. W. Kowall, "Scattering differentiates Alzheimer disease
in vitro," Opt. Lett. 33, 624-626 (2008)


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