Dana Ullmanns Kaspertheater geht weiter.
Andy Lewis hat wieder etwas über Dana Ullman ausgegraben. Diesmal antwortet Dana Ullman im Blog.
(Die Zitate sind im Moment noch nicht vollständig gekennzeichnet. Das kommt demnächst. Deswegen bitte im Originlal bei m Quackometer lesen. Da funktionieren die eingebetteten Links.)
http://www.quackometer.net/blog/2010/10/the-curious-case-of-oxford-university-press-homeopathy-and-charles-darwin.html?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+TheQuackometerBlog+%28the+quackometer+blog%29[*QUOTE*]
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The Quackometer has been developed by Andy Lewis.
The Curious Case of Oxford University Press, Homeopathy and Charles Darwin
October 15, 2010
By Le Canard Noir
A paper on Darwin and Homeopathy was outright rejected by reviewers. It was published anyway. Such is CAM 'research'.Science is a human activity. And as such, it is subject to the full range of fallibilities of thought and action that people are capable of. Within science you will find sloppy and wishful thinking, error and even fraud. But science, rather uniquely, has methods designed explicitly to minimise human biases, reduce error and correct mistakes when they are found. It is this inherent error correction that makes science a reliable source of knowledge about the world.
Peer Review
One of the mechanisms that aims to increase the reliability of the published results of science is peer review. Scientists are required to fully disclose their results and the methods by which they came by those results so that others can criticise, replicate and confirm – or otherwise. But before a paper is published, a journal will ask some other specialists in suitable fields to ensure the results are valid, significant and original. The reviewers check the paper to ensure that a minimum standards of quality is met. This ensures that what we read is a valid contribution to scientific debate.
But peer review itself is not a perfect process. The reviewers can be subject to their own biases – accepting papers that fit their preconceptions or rejection those that might conflict with their own work. Journals have a pecking order of credibility, with the best journals enjoying a reputation for thorough and impartial peer review, whereas those at the bottom can just be seen as promoting special and commercial interests. The process of peer review in these journals is a charade with little real meaning.
At the heart of peer review is trust. We have to assume that editors and reviewers have properly undertaken thorough peer review.
At the heart of peer review is trust. We cannot escape it. We have to assume that, at least in publishing houses and journals that we rate highly, editors and reviewers have properly undertaken thorough peer review, without grace nor favour, and only allowed through the academic work that merits publication. Of course, subsequent errors can be found in peer reviewed work and that is inevitable. Reviewers themselves have to trust that procedures were carried out as described and that mistakes were not made. Peer review is just the first independent layer of checking of results. But the badge of peer review on an article allows the results to be discussed with an authority that could not be achieved prior to publication.
No credence should be placed in the results of CAM journals because of the total lack of effective peer review
Failure of peer review happens across all areas of science, but the publication record with complementary and alternative medicine is especially troubled. So much so, that Professor Barker Bausell, who ran the American National Institute of Health Complementary and Alternative Medicine Specialized Research Center, has written that no credence should be placed in the results of CAM journals because of the total lack of effective peer review. That is not to say that all CAM results are unreliable, but that those published in specialist CAM journals lack rigorous review and, for example, positive results are published regardless of merit and negative results ignored.
Oxford University Press and eCAM
Oxford University Press is a publishing house that deserves a good reputation. However, it has been publishing its own CAM journal, eCAM.
Evidence-based Complementary and Alternative Medicine(eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Surprisingly, and contrary to what you might think given its stance on evidence, this journal is not really thin.
Surprisingly, and contrary to what you might think given its stance on evidence, this journal is not really thin. The journal is filled with all sorts of weird and wonderful papers, a couple of my own recent favourites include, “Clowns Benefit Children Hospitalized for Respiratory Pathologies” (which I am sure they do), and “How Far Can Ki-energy Reach?—A Hypothetical Mechanism for the Generation and Transmission of Ki-energy” (which I am sure is utter nonsense).
One paper that was published earlier this year, caught my eye. Written by America’s chief homeopathic apologist, Dana Ullman, it was entitled “The Curious Case of Charles Darwin and Homeopathy”. Now this surprised me because Ullman had written a book making all sorts of daft claims about Darwin and Homeopathy. I wrote about how Darwin’s own letters allow you to see that he thought homeopathy was absurd and “a subject which makes me more wrath, even than does Clairvoyance”.
A Dismal Paper
Despite this, Ullman used the peer reviewed journal to repeat nonsense about Darwin and homeopathy. In the paper, he makes several claims, the worst being.
1. Firstly, Ullman claims that Darwin might not have lived unless he had been ‘cured’ by homeopathy. It is true that Darwin did take some homeopathy pills (which he said he did “without an atom of faith”) but this was while undergoing other treatments at a hospital in Malvern. Darwin had an undiagnosed disease that came and went throughout his life. Ullman attributes a certain remission to his sugar pill taking – and indeed claims that he only lived because of homeopathy.
2. Ullman writes “After just a month of treatment, Charles had to admit that Gully’s treatments were not quackery after all.”, trying to suggest Darwin had become a convert (not true). There is nothing in his letters to suggest such a thing. To overcome this obvious deficiency in Ullman’s argument, he makes up a fantasy world,
Despite Darwin’s greatly improved health, he never publicly attributed any benefits directly to homeopathy. However, one must also realize that even though homeopathy achieved impressive popularity among British royalty, numerous literary greats, and many of the rich and powerful at that time, there was incredible animosity to it from orthodox physicians and scientists. Because Darwin was just beginning to propose his own new ideas about evolution, it would have been professional suicide to broadcast his positive experiences with homeopathy. Having to defend homeopathy would have damaged his credibility among his colleagues who were extremely antagonistic to this emerging medical specialty.
Given Darwin published one of the most audacious books on science for all time, it is a massive slur to suggest he was a coward when it came to his views on medicine. This passage is nothing short of disgraceful.
3. Ullman claims that Darwin experimented on homeopathic dilutions. Again, this is absurd. Darwin did do groundbreaking research on dilute solutions of ammonia salts on sundew plants, but they clearly were not homeopathic preparations. And Darwin never suggested or believed they were. Ullman desperately wriggles to try to suggest that Darwin was in awe of the power of homeopathy.
In all, the paper is confused and desperate in its attempts to suggest that science history should be rewritten to include Darwin’s so-called experiences and experiments with homeopathy.
A Failure of Peer Review
Why was it published, and why did peer review not stop such obvious drivel from being put in the scientific record?
Well, the paper was peer reviewed and it would appear that it was outright rejected by at least two reviewers. Nonetheless, the paper got published. This is nothing short of a complete breakdown in trust that ought to exist between journal readers and it editorial process.
In fact, I had a discussion with one of the reviewers. He said, “I pointed out the many gaping holes in the narrative – historically inaccurate, factually misleading etc – and recommended outright rejection. Needless to say they asked him to revise and re-submit.”
The reviewer did not expect to have a second chance at reviewing the revised submission. Indeed, he then told me, he had been taken off the list of reviewers at the journal, and was given no reason as to why he was not asked to re-review. Concerns were raised with the editor, Edwin Cooper, but apparently, ‘he did not want to know.’ The reviewer also says that he found out a second reviewer had also advised outright rejection.
Consequences
So, a junk piece of work has been published on the history of Charles Darwin. Does this matter? Ullman’s book, which he has been heavily promoting and using Darwin as one of its central characters is based on the premise that so many ‘cultural heroes’ have used homeopathy that it ought to be taken seriously. It is nothing but quack propaganda – but it may be compelling to many. The fact that Ullman can now boast that his ideas have been published in peer reviewed journals gives his stance an authority that it does not deserve. It is now taken ‘as fact’ that Darwin was cured by homeopathy and did important experiments on it. Other ‘peer reviewed’ papers reference Ullman’s to back this up. (e.g. see here). Quacks, of course embellish even further. For example, a homeopath called Karivaj writes, “He discovered that however much he reduced the dose of the substance he used, salt of ammonia – prepared according to the homoeopathic method with dilution and succussion – the effects were always visible in the plant.”. This is simply not true.
Ullman himself now boasts of this paper’s peer reviewed status. On an online discussion, he taunted me,
I have published in peer-review journals on Darwin and his homeopathic doctor. Please enlighten me where your writings on this subject have appeared. Oh, in your own blog! Wow, now THAT is high quality pee-review. Yeah, that typo is purposeful. You’re good a yellow journalism.[sic]
All this does is add to the fog of intentional confusion and dishonesty that surrounds alternative medicine. There is indeed an important need for sound research to be published about CAM. We need to understand why people are drawn to superstitious treatments, what are the potential harms – and what benefits, if any, might be expected. But CAM research is so full of propaganda masquerading as serious academic research that it is a constant battle to have to point out why so many conclusions in the field are not worth anything. This can only harm people – it actually risks people’s health and life. And that is why failures of peer review are not just a breach of trust but of deep moral concern.
Fortunately, it is possible that Oxford University Press have seen good sense and decided that they do not want such a journal sullying their reputation. It has now been sold to Indian publisher Hindawi.
Related posts:
A Footnote to Darwin and Homeopathy The homeopaths, like Dana Ullman, treat original scientific works like scripture – as a source of truth. Their own Hahnemannian scriptures trump scientific knowledge and evidence at all turns. This...
Charles Darwin and Homeopathy The Internet is a wonderful thing. It allows you check stuff, like the claims of quacks, in a way that was not possible just a few years ago. This...
UK Hospital HR Manager in ‘Near Death Experience’ Let’s recap – ‘Cellular Memory’ – the alleged ability for every cell to retain some sort of energy memory about us that can get passed on through organ transplants to...
The Homeopathic Revolution by Dana Ullman: A Review There can be few comment-enabled web pages left in the world that do not testify to the fact that Dana Ullman has published his latest book: The Homeopathic Revolution:...
The Two Most Dangerous Words in Medicine are "Studies Show." Jerry Addler has published his New Year’s resolution in Newsweek, I will not report on any amazing new treatments for anything, unless they were tested in large, randomized, placebo-controlled, double-blind...
Tags: dana ullman, homeopathy
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25 Responses to “ The Curious Case of Oxford University Press, Homeopathy and Charles Darwin ”
Dr Aust on October 15, 2010 at 4:30 pm
Waiting….
…..for DUllman….
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Rocko on October 15, 2010 at 5:14 pm
Excellent article.
The fact is that Ullman knows that there is zero evidence that Darwin was a homeopathy convert; this has been pointed out to him on numerous occasions. And yet he repeats the claim constantly regardless.
Of course the same is true of all his claims, but the Darwin one is so transparently false I cannot believe he believes it himself. One may take a view on what this says about his motives for his ceaseless pushing of homeopathy.
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Dana Ullman on October 15, 2010 at 10:17 pm
Hey Rocko and Mr. Duck,
Show me (and the rest of us) where I wrote that Darwin was a “convert” to homeopathy. Whooops…you cannot do that because you’re making things up (again).
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Vicky on October 15, 2010 at 10:44 pm
Where did Andy write that you said he was a convert? Or is there a chance you’re making that up? Here’s what I read (copied from above):
Ullman writes “After just a month of treatment, Charles had to admit that Gully’s treatments were not quackery after all.”, trying to suggest Darwin had become a convert (not true).
(emphasis added)
You did write that, didn’t you?
Rocko on October 16, 2010 at 1:11 pm
Transparent weasel words as ever, Dana. You’ve constructed this elaborate scenario (albeit one completely unencumbered by evidence) where Darwin went from being “scathing” about homeopathy to only not speaking up for it because:
“Having to defend homeopathy would have damaged his credibility among his colleagues”
A conversion, in other words.
Dana Ullman on October 15, 2010 at 6:17 pm
It might help if Mr. Duck actually read my peer-review article rather than make-up things out of thin air.
Actually, I acknowledged in my article that Darwin was a skeptic of homeopathy…and I gave appropriate references to this…and THAT is also what makes Darwin’s story so compelling. He proves that belief is NOT necessary to get real benefits from homeopathic treatment and hydrotherapy (water-cure). Are you ACTUALLY saying that Darwin did not get therapeutic benefits from Dr. Gully’s treatment? Are you actually re-writing history?
Is it a “coincidence” that wrote that he was dying just prior to going to Dr. Gully and that he was unable to work 1 in every 3 days…and yet, within a couple of weeks, he was able to walk 7 miles in a day and he called himself “an eating and walking machine.” Oh, and what happened to the symptoms that he was experiencing for 2 to 12 (!) years, including heart palpitations, fainting spells, spots before his eyes, body-wide boils, and extreme fatigue? Darwin never again mentioned ANY of these symptoms after the first couple of weeks under Gully’s treatment.
Mr. Duck, you’re good at leaving out information…but I do want to thank you for reference my comment about your yellow journalism. At least I have a sense of humor…
As for Darwin’s experiments with the Drosera plant…can you, Mr. Duck, tell me if Darwin was or wasn’t surprised at the significant effects that he observed from exceedingly small doses of ammonia salts? Tell me, Mr. Duck, why did he have BOTH of his sons repeat his experiments and continue to express amazement? Oh…and tell me, did Darwin express concern that he would then have to report about these experiments that shocked him so much? C’mon…man up and say what is true.
I provide references to my information. You provide a thin review that is full of misinformation. I encourage readers to actually read my article and not blindly accept Mr. Duck’s weak summary of it.
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Daniel Rendall on October 15, 2010 at 8:34 pm
How small were the exceedingly small doses of ammonia salts?
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Dana Ullman on October 15, 2010 at 10:15 pm
Thanx for your interest, Daniel, but I hope you understand that this AND other information about this issue are in my peer-review article at:
http://ecam.oxfordjournals.org/cgi/content/full/7/1/33 Quoting from da man (Darwin), he wrote:
“The reader will best realize this degree of dilution by remembering that 5,000 ounces would more than fill a thirty-one gallon cask [barrel]; and that to this large body of water one grain of the salt was added; only half a drachm, or thirty minims, of the solution being poured over a leaf. Yet this amount sufficed to cause the inflection of almost every tentacle, and often the blade of the leaf. … My results were for a long time incredible, even to myself, and I anxiously sought for every source of error. … The observations were repeated during several years. Two of my sons, who were as incredulous as myself, compared several lots of leaves simultaneously immersed in the weaker solutions and in water, and declared that there could be no doubt about the difference in their appearance. … In fact every time that we perceive an odor, we have evidence that infinitely smaller particles act on our nerves.” (p. 170)
Malcolm Armsteen on October 15, 2010 at 6:39 pm
Am I convinced by Ms Ullman’s riposte? Only 10^23 much.
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hat_eater on October 15, 2010 at 10:49 pm
Oh, what a magnificent idea. I’m gonna butcher a rich widow with an axe and then proceed to sell the axe to my neighbour. Surely noone will make a connection.
In my eyes, Oxford University Press has tarnisher its reputation for years.
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Nash on October 15, 2010 at 11:26 pm
I take it that Daniel is Dullman’s new sock puppet?
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phayes on October 16, 2010 at 12:07 am
I wonder if this anachronistic revelation that an insectivorous plant’s “nose” is sensitive to very dilute (~10⁻⁹?) but certainly not very homeopathic solutions means that Ullman has at last seen the light as far as homeopathy is concerned and ditched it in favour of aromatherapy (albeit a new and even less plausible version of it)?
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L I N K S « The Dispersal of Darwin on October 16, 2010 at 1:44 am
[...] The Quackometer: The Curious Case of Oxford University Press, Homeopathy and Charles Darwin [...]
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Michael5MacKay on October 16, 2010 at 2:59 am
Ullman’s article couldn’t have been peer-reviewed. For unscientific nonsense, he is peerless. In any event, his article is not science and certainly not evidence of the effectiveness of homeopathy.
Ullman’s article is the most mendacious piece of English prose I have ever read. He said, as Vicki already noted:
“After just a month of treatment, Charles had to admit that Gully’s treatments were not quackery after all.” He didn’t have to admit any such thing, and I doubt very much that he did make any such admission. If he had, I’m sure Ullman would have mentioned it.
There is no basis for believing that homeopathy was of any benefit to Darwin. Ullman can’t even identify Darwin’s condition; therefore Ullman didn’t, and can’t, point to any scientific evidence that homeopathy is an effective treatment for it, or indeed any specific non-self limiting condition. Any study he might choose to cite has already been thoroughly debunked.
Ullman has no basis for claiming that homeopathy cured Darwin. How could he know that it wasn’t the hydrotherapy, or, more likely a remission or resolution of a chronic or self-limiting condition? He can’t. The fact that he makes the claim shows that Ullman will say anything to support his belief in homeopathy, the epitome of quack medicine. Ullman is wrong. Homeopathy has had 200 years to prove itself. It hasn’t. There is a growing body of evidence that shows it does not work. The more Ullman attempts to defend the indefensible, the more foolish he reveals himself to be.
Even the NHS now recognizes that homeopathy doesn’t work, as shown by its progressive withdrawal of funding. It is not surprising that Ullman can’t see what more and more people are seeing once they look carefully at the evidence relating to homeopathy. As Uptown Sinclair said, “It is difficult to get a man to understand something when his salary depends upon his not understanding it.”
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Martin on October 16, 2010 at 9:09 am
Just a little reminder to all that abuse diluted by a great deal of reasoning is more potent.
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Martin on October 16, 2010 at 9:17 am
“Dr Jütte notes that in the introduction to this book (p. xv) Koch explains homeopathy scientifically by including it in a more general ‘Grundgesetz des organischen Lebens’, which could be translated as ‘law of spirality’.” – from the article we are discussing.
Who would translate ‘Grundgesetz’ as ‘Law of spirality’? My native tongue is not German. Anyone?
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JimR on October 16, 2010 at 11:06 am
“Basic Law of Organic Life” is the Google translation for ‘Grundgesetz des organischen Lebens’. WOW! This would make homeopathy the unknown start of life as we know it. There was a primordial spark that, after it was diluted sufficiently by the water from the early bombardment by icy comets and asteroids, came “alive”? That would be really convincing for the power of dilution.
If one reviews a paper and has the work thrown back at one, it seems it were best to be struck off the list of reviewers. It is a lot of bother to do a good review.
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Mojo on October 16, 2010 at 11:02 pm
The section of the article about the “German homoeopathic doctor” is a little odd. The quotation from Darwin used to support it is described in the article as “an August 20, 1862, letter to Asa Gray”, but the passage quoted actually describes it as “an example of the odd letters he received” rather than one sent. The reference given is to a 1903 New York edition of Francis Darwin’s Life and Letters of Charles Darwin. I can’t find this particular edition online, but the passage appears in Vol 2 of the original 1887 edition, in the introduction to the letters of 1862 on page 383.
Tracking it down to the letter Darwin’s comments originally appeared in, it turns out to have been a postscript to a letter to Joseph Hooker dated 16 Jan 1862. This makes it even more clear that it is actually a comment on a letter received:
“P.S. The letter with curious address forwarded by Mrs Hooker was from a German Homœopathic Doctor—an ardent admirer of the Origin—had himself published nearly the same sort of book, but goes much deeper—explains the origin of plants & animals on the principles of Homœopathy or by the Law of Spirality— Book fell dead in Germany— Therefore would I translate it & publish it in England &c &c?!”
There is no indication here that Darwin had read the book, or even seen a copy of it; rather he seems to have been commenting on the contents of the “letter with curious address” that had been forwarded to him. There doesn’t seem to be any indication of “admiration” for this German homoeopath either.
Mojo on October 16, 2010 at 11:06 pm
For some reason the link to the Life and Letters of Charles Darwin in my last post doesn’t seem to work. I’ll try posting it again.
John Benneth on October 16, 2010 at 7:41 pm
Ah yes, the wonderful Darwin drosera experiments. Kudos to Dana Ullman for once again succussing the dimwit and making fools of the anti-homeopathy tribe.
Hey, I did video on it:
The mark of pseudoscience is a lack of specificity. Same with liars and Andy Lewis. You ask for details, and they suddenly go blank. And of course the case against homeopathy is just the same. They keep saying that there is a growing body of evidence that disproves it, but you look for the specifics, references, cites, and they aren’t there. Shang refuses to name its references as well, and if that weren’t enough, comes to a somewhat vague conclusion, contradicted by every other major meta analysis.
The Lewis’ of the world can’t even tell you reallywhat a placebo is, much less cite any psychogenic studies for their action. Oh, they say homoeopathy isn’t much better than placebo, then in the net breath are defending placebo as a powerful effect.
Yes, its true, the effects of homeopathics are not stable, but there are effects beyond placebo, and Darwin’s drosera rotund flora proves it, because logically a plant would not be subject to placebo. But Heavens to God, Lewis will never put it to the test with a real homeoapthic dilution of ammonia carbonicum 12c or more, nor will he ever consider trying it on a bean other than his own, which he won‘t do either. But it has been proven on beans, and it has been tried on wheat extensively. Plants make excellent test subjects for demonstrating the action of homeopathic remedies beyond palcebo, numerous, cheap, easily controlled, no ethical considerations, and according to Vaikunthanath das Kaviraj, author of Homeopathy for Farm and Garden, there are over 60 studies now for the action of homeopathics on plants.
Run Andy, run. Run away from this proving, it does nothing but epose you for the fool you are.
Here’s an example of work that has been done at one of the world’s oldest and most respected universities:
“Statistical analysis of the effect of high dilutions of arsenic in a large dataset from a wheat germination model” Brizzi M, Nani D, Peruzzi M, Betti L. Dipartimento di Scienze statistiche, University of Bologna, Italy Br Homeopath J. 2000 Apr;89(2):63-7 This has been rep[eated ad nauseam. Google it!
Of course they’ll rip this one apart because it wasn’t published in THEIR review, it was published in the peer review of the doctrine. Such will always be the reaction of those who replace the opportunity to experience something for themselves with maligning extrapolation of the reports of others who have. But where else would you expect to find it? Nothing so controversial as this is go0ing to easily find it’s way into a general science magazine like Scientific American, and so it speaks volumes that Ullman’s article has been accepted in such a publication, as have, by my count, about two dozen others.
But what will they do when they face the stack of replications?
The evidence for homeopathy is of course concordant, as it would be for any real effect, and that’s why it has withstood two centuries of vicious opposition, like Lewis’ here, because there will always be those like Darwin who, after being totally dismissive, have been dramatically affected by it. Lewis and those like him are doing nothing more than simply using the appearance of what they think is an anomaly as an excuse to malign those who find application for it. They do the same thing to Christianity or any spiritual belief whenever they can sneak it in.
The homeopathy denier, in order to fund his disbelief, has to think that those who report favorably on it must be suffering from gullibility. Such is not the case. The best supporters of homeoapthy are usually those who are the most critical thinkers and who in the beginning of their investiagtion attacked it on the same grounds as Lewiset al does. The difference is that real skeptics put it to the test . . On themselves and other test subjects, like plants. I have. I found Staphyssagria had astounding effects on the growth of oat coleoptiles.
It doesn’t stand to reason, to a thinking man, that extrapolation by a few should trump direct observation by many, even though what is being observed doesn‘t make any sense. But after you see so much thought and effort into indexing its effects by true medical doctors, you have to consider that maybe, just maybe, there is a logical explanation for it. Supramolecualr chemistry provides that, and recent experiments have demonstrated the structure, radiant signal, biochemical and biologicial action of the homeopathic remedy that makes criticism by the likes of Lewis and company seem absolutely puerile and vituperatively ad hominem, as one can read here repeatedly in Lewis’ libel and tortious interference.
Ullman presents a startling array of evidence for homeopathy in his book “The Homeoapthic Revolution,” but most damning to the case against homeopathy is the phytopatholgical illustrated in the Darwin imbroglio, and it reveals the pseudoscience in the criticism against homeoapthy.
Three cheers for Dana Ullman!
John BENNETH 101610
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Vicky on October 16, 2010 at 9:52 pm
Actually, this is a case of tl;dr
However,
Shang refuses to name its references as well, and if that weren’t enough, comes to a somewhat vague conclusion, contradicted by every other major meta analysis.
what are you talking about? The web appendices of Shang et al. cite them and have been available for years now. How do you think Lüdtke&Rutten got them – clairvoyance?
Also, where are those other major meta-analyses that contradict Shang et al.? Only real scientific journals, please.
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John Benneth on October 17, 2010 at 1:26 am
Alright, I concede that “Shang refuses” refers to Shang’s presiding investigator Egger’s initial refusal to name his references, which, as it can be seen, is because Egger didn’t want to name them that his meta analysis was nothing more than another smear job on the field. Like all cirtics of homeopathy, in order to maintain the Placebo Hypothesis, he has to ignore the pre-clinicals and cherry pick the clinicals.
Shang is the only major review to make conclude that homeopathics are no better than placebo, but even Shang contradicts itself to say “there was weak evidence for a specific effect of homoeopathic remedies.”
No other meta or review, mlisted below, concludes placebo.
Here’s a section from my notes, “Science of homeopathy.”
The Truth about Shang
The 2005 Shang meta-analysis in Lancet found homeopathics no different than placebo. But Shang’s flawed on many levels. It eliminated 102 of 110 homeopathic trials, basing its conclusions on only the 8 largest high-quality trials without identifying the criteria by which trials were selected or their identity. Odds ratios did not support their conclusion that homeopathics are no better than placebo. “Where Does Homeopathy Fit in Pharmacy Practice?” Am J Pharm Educ.
Shang A, Huweiler-Muntener K, Nartey L, et al. Are the clinical effects of homeopathy placebo effects? Comparative study of placebo-controlled trials of homeopathy and allopathy. Lancet. 2005;366:726–32. [PubMed]
Fisher P Homeopathy and The Lancet Evid Based Complement Alternat Med. 2006 March; 3(1): 145–147 [PubMed]
Kiene H, Kienle GS, von Schön-Angerer T. Bias in meta-analysis. Homeopathy. 2006;95:54. [PubMed]
Bell I. All evidence is equal, but some evidence is more equal than others: Can logic prevail over emotion in the homeopathy debate? J Alternative Complement Med. 2005;11:763–9.
Aikin K. The end of biomedical journals: there is madness in their methods. J Alternative Complement Med. 2005;11:755–7.
Swiss Association of Homeopathic Physicians. Open letter to the editor of the Lancet. Forsch Komplementarmed Klass Naturheilkd. 2005;12:352–3. [PubMed] [PDF]
Shah A. Is the Lancet trial really valid? Pharm J. 2005;275:407.
The 2005 Lancet review proved superior quality of homeopathy trials. Lex Rutten Opening lecture at the LMHI congress 2009, Warsaw
http://www.dokterrutten.nl/collega/Liga09.pdf Homeopathy in Meta-analysis
and Review
2009 FISHER: Homeopathy: the Evidence from Basic Research Memorandum submitted to Parliament Goto article
2009 FISHER: Annual Evidence Update on Homeopathy. NHS Goto article
2007 JOHNSON: Where Does Homeopathy Fit in Pharmacy Practice? Am J Pharm Educ. Goto full article
Johnson is a comprhensive review written of homeoapthics by pharmacists for pharmacists, covering both pro and con.
2007 WITT: The in vitro evidence for an effect of high homeopathic potencies–a systematic review of the literature. Complement Ther Med. Goto abstract
In this review Witt uses an established criteria for rating homeoapthy experiments, something of course maligners like Lewis and Egger are incapable of doing. SI different types of biochmeical tests are covered, from the 1930’s to 2007. The most replicated biuochemical test is the basopphil degranulation.
2005 Shang: Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet Goto abstr.
Review of the House of Common’s Evidence Check by Earl Baldwin of Bewdley.
2.1. There have been a number of systematic reviews and meta-analyses in this
field, which as the Committee states are the best sources of evidence. The
most recent review of substance is that by Shang et al in 2005, which it
considered “the most comprehensive to date” and which compared 110
placebo-controlled trials of homoeopathy [authors’ spelling] with 110 trials of
conventional medicine matched for disorder and type of outcome. The
Committee cited a conclusion by the authors [paragraph 69] that “when
analyses were restricted to large trials of higher quality there was no convincing
evidence that homeopathy [sic] was superior to placebo”. They did not
also cite the authors’ interpretation which followed these findings in the
Lancet summary, which stated: “When account was taken for these biases
[common to trials of both homoeopathy and conventional medicine], there
was weak evidence for a specific effect of homoeopathic remedies, but strong
evidence for specific effects of conventional interventions. This finding is
compatible with the notion that the clinical effects of homoeopathy are
placebo effects.”
2.2. This was no endorsement of homeopathy. But it was some way removed
from the Committee’s conclusion in paragraph 70 of their report, “In our view,
the systematic reviews and meta-analyses conclusively demonstrate that
homeopathic products perform no better than placebos.” It also provides
little support for that part of Professor Ernst’s evidence to the Committee
where he “pointed out that: . . . Shang et al very clearly arrived at a
devastatingly negative overall conclusion” [67].
2.3. The exaggeration by the Committee of Shang’s conclusions is worrying. It is
difficult to see how a weakly supported positive effect, for which one
explanation (possibly well-founded) is a placebo effect, can be translated into
a conclusive demonstration of this effect, with a “devastatingly” negative
finding. No such firm claims can be found in Shang, who writes of finding
“no strong” evidence, or “little” evidence, and who ends his paper with
cautions about methodology and about the difficulty of detecting bias in
studies, as well as the role of possible “context effects” in homeopathy.
From Observations on the report Evidence Check 2: Homeopathy by the House of Commons Science and Technology Committee, February 2010
2003 BECKER-WITT Quality Assessment of Physical Research in Homeopathy. J Alt Comp Med Abstract
In this study Becker-Witt establishes the scoring system for assessing the quality of homeopathic trials, the same as used in the in vitro review. It analyzes six different types of physical expriments used to analyze homeoapthic remedies, the most common being NMR.
2003 JONAS- A Critical Overview of Homeopathy Annals of Internal Medicine
http://www.annals.org/content/138/5/393.full2001 LINDE Systematic reviews of complementary therapies – an annotated bibliography. Part 3: homeopathy. “While the evidence is promising for some topics the findings of the available reviews are unlikely to end the controversy on this therapy.” BMC Complement Altern Med. PUBMED
2000 CUCHERAT: Evidence of clinical efficacy of homeopathy. A meta-analysis of clinical trials. Euro J Clin Pharm Goto review ; PUBMED abstract
1997 LINDE: Are the Clinical Effects of Homeopathy Placebo Effects? A Meta-analysis of Placebo-Controlled Trials The results of our meta-analysis are not compatible with the hypothesis that the clinical effects of homoeopathy are completely due to placebo. Lancet 1997; 350: 834–43 Goto article
This is the most noted and respected meta.
1994 LINDE: Critical Review and Meta-Analysis of Serial Agitated Dilutions in Experimental Toxicology Abstract; PDF
1991 KLEIJNEN: Clinical Trials of Homeopathy Goto full article
1984 SCOFIELD: Experimental research in homœopathy—a critical review Abstract
Scofield is especially good, because whereas it is critcal of methods, it also identifies high quality pre-clinicals up to 1984, most notably Boyd.
The question tht should be asked first is if it can be demonstrated that homeopathics have biological effects, not if it is a “placebo.”
John BENNETH
John Benneth on October 16, 2010 at 7:45 pm
Video on Darwin’s experiments
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Mojo on October 16, 2010 at 9:58 pm
If you actually read Darwin’s accounts of the Drosera experiments in Insectivorous Plants (see Chapter 7 on pp.136-173) you will find no mention of serial dilution or succussion being used in the preparation of the solutions Darwin used.
You will also find that Darwin established something like an orthodox dose-response curve (Note for example the comment on p.171 that “It is to be especially observed that the experiments with the weaker solutions ought to be tried after several days of very warm weather. Those with the weakest solutions should be made on plants which have been kept for a considerable time in a warm greenhouse, or cool hothouse; but this is by no means necessary for trials with solutions of moderate strength”) and a limit beyond which no response was observed. Note also p.170, with the footnote in which Darwin notes that in the detection of dilute substances “the spectroscope has altogether beaten Drosera.”
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JimR on October 17, 2010 at 1:08 am
I worry that the edifice of science is being eroded by the persistent, arrogant, denigrating, knuckle-headed denials of alt-med champions. It has taken centuries to build such an edifice, but so many people seem to be helping tear down such wonderful work. Will we see homeopaths trying to defend their profession against spiritualists claiming that their blessed waters are cures, not the dilutions of the homeopaths? There is potential irony that one system may displace another because systems of proof were discarded. At this rate will we face a declining science based civilization? I hope not.
There doesn’t seem to be any level of embarrassment that an alt-med promoter cannot withstand. Are these people sociopaths, misguided, or driven by greed to delude people to take useless potions and avoid science-based cures? Sure there are no cures for many things, but to unknowingly or worse to knowingly flim-flam people and prey on false hopes is just sick.
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