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Autor Thema: Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism  (Gelesen 1406 mal)


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Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism

Vera Gorbunovaa,1, Christopher Hinea,2, Xiao Tiana, Julia Ablaevaa, Andrei V. Gudkovb, Eviatar Nevoc,1, and Andrei Seluanova,1

 Author Affiliations
aDepartment of Biology, University of Rochester, Rochester, NY 14627;
bDepartment of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263; and
cInstitute of Evolution, University of Haifa, Haifa 31905, Israel

Contributed by Eviatar Nevo, October 3, 2012 (sent for review August 28, 2012)

Blind mole rats Spalax (BMR) are small subterranean rodents common in the Middle East. BMR is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer. Spontaneous tumors have never been observed in spalacids. To understand the mechanisms responsible for this resistance, we examined the growth of BMR fibroblasts in vitro of the species Spalax judaei and Spalax golani. BMR cells proliferated actively for 7–20 population doublings, after which the cells began secreting IFN-?, and the cultures underwent massive necrotic cell death within 3 d. The necrotic cell death phenomenon was independent of culture conditions or telomere shortening. Interestingly, this cell behavior was distinct from that observed in another long-lived and cancer-resistant African mole rat, Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity to contact inhibition. Sequestration of p53 and Rb proteins using SV40 large T antigen completely rescued necrotic cell death. Our results suggest that cancer resistance of BMR is conferred by massive necrotic response to overproliferation mediated by p53 and Rb pathways, and triggered by the release of IFN-?. Thus, we have identified a unique mechanism that contributes to cancer resistance of this subterranean mammal extremely adapted to life underground.

?1To whom correspondence may be addressed.
E-mail:,, or

?2Present address: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115.

Author contributions: V.G., A.V.G., E.N., and A.S. designed research; C.H., X.T., J.A., and A.S. performed research; A.V.G. and E.N. contributed new reagents/analytic tools; V.G., E.N., and A.S. analyzed data; and V.G., E.N., and A.S. wrote the paper.

The authors declare no conflict of interest.


Articles by Vera Gorbunova:
Würde ich von Licht leben,
müßte ich grün sein.